Fanconi Anemia Associated Protein 24kDa (FAAP24)

FAAP24 is a component of the Fanconi anemia (FA) core complex, which plays a crucial role in DNA damage response. FAAP24 interacted specifically with the C-terminal region of FANCM in several assays. In fractionated HeLa cells, the FAAP24/FANCM heterodimer associated with other FA core proteins in an 800-kD complex. Downregulation of FAAP24 by small interfering RNA resulted in reduced levels of monoubiquitylated FANCD2 after exposure to DNA crosslinking reagents.

FAAP24 bound single-stranded DNA. FAAP24 promotes targeting of FANCM/FAAP24 dimers, and possibly other components of the FA core complex, to forked DNA intermediates generated after DNA damage.