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Uracil Phosphoribosyltransferase (UPRT)

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FUR1

Uracil Phosphoribosyltransferase (UPRT)
CCC M983
HGNC 28334
MGI 2685620
PubMed 23444104
RGD 1564806
UniProt Q96BW1
UPRT encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer.
The deduced 309-amino acid protein contains a putative uracil phosphoribosyltransferase domain and has a calculated molecular mass of 33.8 kD. RT-PCR detected high UPRT expression in blood leukocytes, liver, spleen, and thymus, with lower expression in prostate, heart, brain, lung, and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM983Hu01 Recombinant Uracil Phosphoribosyltransferase (UPRT) Positive Control; Immunogen; SDS-PAGE; WB.
APM983Hu01 Active Uracil Phosphoribosyltransferase (UPRT) Cell culture; Activity Assays.
Antibodies PAM983Hu01 Polyclonal Antibody to Uracil Phosphoribosyltransferase (UPRT) WB; IHC; ICC; IP.
MAM983Hu21 Monoclonal Antibody to Uracil Phosphoribosyltransferase (UPRT) WB; IHC; ICC; IP.
Assay Kits SEM983Hu ELISA Kit for Uracil Phosphoribosyltransferase (UPRT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Uracil Phosphoribosyltransferase (UPRT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Uracil Phosphoribosyltransferase (UPRT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Uracil Phosphoribosyltransferase (UPRT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Uracil Phosphoribosyltransferase (UPRT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Uracil Phosphoribosyltransferase (UPRT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Uracil Phosphoribosyltransferase (UPRT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Uracil Phosphoribosyltransferase (UPRT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Uracil Phosphoribosyltransferase (UPRT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Uracil Phosphoribosyltransferase (UPRT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Uracil Phosphoribosyltransferase (UPRT) ELISA Kit Customized Service Offer
  1. "Identification and characterization of human uracil phosphoribosyltransferase (UPRTase)."J. Hum. Genet. 52:415-422(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]