Tubulin Folding Cofactor E Like Protein (TBCEL)
[Edit]LRRC35; EL; Leucine Rich Repeat Containing 35; Tubulin-Specific Chaperone E-Like
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LRRC35 did not play a role in tubulin heterodimer assembly and had no effect on the tubulin GTPase activity of cofactor C (TBCC) and cofactor D (TBCD). Overexpression of LRRC35 caused microtubule destruction by disrupting tubulin heterodimers and targeting tubulin to the proteasome for degradation. cells depleted of LRRC35 retained stable microtubules, mostly concentrated in the perinuclear region, and displayed a clustering of endoplasmic reticulum, Golgi, and lysosomal organelle membranes in a condensed region of the cytoplasm. LRRC35 regulation of microtubule network stability affects vesicle trafficking mediated by microtubule-dependent molecular motors.The deduced 425-amino acid protein shares 23% amino acid identity with TBCE and contains a leucine-rich repeat followed by a ubiquitin-like motif.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Tubulin Folding Cofactor E Like Protein (TBCEL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Tubulin Folding Cofactor E Like Protein (TBCEL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Tubulin Folding Cofactor E Like Protein (TBCEL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Tubulin Folding Cofactor E Like Protein (TBCEL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tubulin Folding Cofactor E Like Protein (TBCEL) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Tubulin Folding Cofactor E Like Protein (TBCEL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Tubulin Folding Cofactor E Like Protein (TBCEL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Tubulin Folding Cofactor E Like Protein (TBCEL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Tubulin Folding Cofactor E Like Protein (TBCEL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tubulin Folding Cofactor E Like Protein (TBCEL) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Tubulin Folding Cofactor E Like Protein (TBCEL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Tubulin Folding Cofactor E Like Protein (TBCEL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Tubulin Folding Cofactor E Like Protein (TBCEL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Tubulin Folding Cofactor E Like Protein (TBCEL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tubulin Folding Cofactor E Like Protein (TBCEL) | ELISA Kit Customized Service Offer |
- "Identification of a novel tubulin-destabilizing protein related to the chaperone cofactor E."J. Cell Sci. 118:1197-1207(2005) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]