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H2B Histone Family, Member W, Testis Specific (H2BFWT)

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Histone H2B type W-T

H2B Histone Family, Member W, Testis Specific (H2BFWT)
CCC N028
HGNC 27252
PubMed 15237208
UniProt Q7Z2G1
Wiki H2BFWT
Testis-specific histones, like H2BFWT, are synthesized and accumulate at specific stages of mammalian spermatogenesis. The deduced 175-amino acid protein shares 43% and 46% identity with the somatic H2B.1 protein and the testis/sperm-specific TSH2B protein, respectively. Highest similarity is in the C-terminal canonical H2B domains. Database analysis indicated that the H2BFWT gene is conserved among primates and is apparently absent from rodents. PCR of several tissues detected
H2BFWT expression in testis only. Immunolocalization detected H2BFWT at the nuclear membrane of sperm cells. H2BFWT showed even nuclear staining in 10% of transfected Chinese hamster fibroblasts and colocalized with telomeric sequences in large nuclear bodies in the other 90%.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant H2B Histone Family, Member W, Testis Specific (H2BFWT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to H2B Histone Family, Member W, Testis Specific (H2BFWT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to H2B Histone Family, Member W, Testis Specific (H2BFWT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for H2B Histone Family, Member W, Testis Specific (H2BFWT) CLIA Kit Customized Service Offer
n/a ELISA Kit for H2B Histone Family, Member W, Testis Specific (H2BFWT) ELISA Kit Customized Service Offer
  1. "Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome."Genomics 84:745-756(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes."Mol. Cell. Biol. 26:1518-1526(2006) [PubMed] [Europe PMC] [Abstract]