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Notum Pectinacetylesterase Homolog (NOTUM)

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Notum Pectinacetylesterase Homolog (NOTUM)
CCC N029
HGNC 27106
MGI 1924833
PubMed 18429952
UniProt Q6P988
Giraldez et al. (2002) cloned Drosophila Notum and identified homologs in several species, including mouse and human. Notum has a highly conserved 325-amino acid region that includes an active-site motif (GxSxG), termed a 'nucleophile elbow,' that is part of the ser-asp-his catalytic triad characteristic of hydrolases.
Giraldez et al. (2002) demonstrated that Drosophila Notum is a secreted enzyme that can shape the extracellular wingless gradient by modifying cell surface heparin sulfate proteoglycans.
Hartz (2006) mapped the NOTUM gene to chromosome 17q25.3 based on an alignment of the NOTUM sequence with the genomic sequence (build 35).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Notum Pectinacetylesterase Homolog (NOTUM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Notum Pectinacetylesterase Homolog (NOTUM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Notum Pectinacetylesterase Homolog (NOTUM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Notum Pectinacetylesterase Homolog (NOTUM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Notum Pectinacetylesterase Homolog (NOTUM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Notum Pectinacetylesterase Homolog (NOTUM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Notum Pectinacetylesterase Homolog (NOTUM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Notum Pectinacetylesterase Homolog (NOTUM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Notum Pectinacetylesterase Homolog (NOTUM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Notum Pectinacetylesterase Homolog (NOTUM) ELISA Kit Customized Service Offer
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient."Dev. Cell 2:667-676(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF."Cancer Sci. 99:1139-1146(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Notum deacylates Wnt proteins to suppress signalling activity."Nature 519:187-192(2015) [PubMed] [Europe PMC] [Abstract]