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DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24)

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ZCSL3; DPH4; JJJ3; Zinc Finger,CSL-Type Containing 3; DPH4 Homolog; Diphthamide biosynthesis protein 4

DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24)
CCC N041
HGNC 26979
MGI 1919522
RGD 1564710
UniProt Q6P3W2
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2.
Liu et al. (2004) identified 2 variants of mouse Dph4 that encode proteins of 193 and 148 amino acids. Both isoforms contain an N-terminal DnaJ domain and a C-terminal CSL zinc finger domain. Mouse and human DPH4 share 83% amino acid identity.The International Radiation Hybrid Mapping Consortium mapped the DPH4 gene to chromosome 11.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) CLIA Kit Customized Service Offer
n/a ELISA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) CLIA Kit Customized Service Offer
n/a ELISA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) CLIA Kit Customized Service Offer
n/a ELISA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 24 (DNAJC24) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy."Proc. Natl. Acad. Sci. U.S.A. 109:6898-6903(2012) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4."J. Biol. Chem. 287:13194-13205(2012) [PubMed] [Europe PMC] [Abstract]
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]