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Fanconi Anemia Associated Protein 100kDa (FAAP100)

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C17orf70

Fanconi Anemia Associated Protein 100kDa (FAAP100)
CCC N105
HGNC 26171
MGI 1919135
PubMed 17396147
RGD 1306926
UniProt Q0VG06
FAAP100 is a component of the Fanconi anemia (FA) core complex and is required for core complex stability and FANCD2 monoubiquitination.
The nuclear localization of FAAP100 was defective in cells with deficiency of FANCA or FANCM. When FAAP100 was depleted in HeLa cells with siRNA oligos, the other components of the core complex also were reduced. Ling et al. (2007) created a knockout chicken B-cell line for the avian FAAP100 gene and found that the cellular phenotype had the hallmarks of Fanconi anemia, including hypersensitivity to DNA crosslinking drugs and MMC-induced chromosomal breakage. Ling et al. (2007) concluded that FAAP100 is an essential component of the FA-BRCA-associated network that responds to DNA damage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Associated Protein 100kDa (FAAP100) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Associated Protein 100kDa (FAAP100) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Associated Protein 100kDa (FAAP100) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Associated Protein 100kDa (FAAP100) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Associated Protein 100kDa (FAAP100) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Associated Protein 100kDa (FAAP100) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Associated Protein 100kDa (FAAP100) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Associated Protein 100kDa (FAAP100) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Associated Protein 100kDa (FAAP100) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Associated Protein 100kDa (FAAP100) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Associated Protein 100kDa (FAAP100) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Associated Protein 100kDa (FAAP100) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Associated Protein 100kDa (FAAP100) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Associated Protein 100kDa (FAAP100) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Associated Protein 100kDa (FAAP100) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway."EMBO J. 26:2104-2114(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]