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tRNA Methyltransferase 1 Homolog (TRMT1)

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TRM1; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(m(2,2)G26)dimethyltransferase; tRNA (guanine(26)-N(2))-dimethyltransferase

tRNA Methyltransferase 1 Homolog (TRMT1)
CCC N125
HGNC 25980
MGI 1289155
RGD 1305992
UniProt Q9NXH9
tRNA methyltransferase-1 catalyzes dimethylation at the exocyclic 2-amino group of guanine 26 in tRNAs using S-adenosyl-L-methionine as substrate.
The human cDNA encodes a deduced 659-amino acid protein that is 26% and 31% identical to the yeast and C. elegans homologs, respectively. When the human protein was expressed in E. coli, which lacks tRNA(m2,2G)dimethyltransferase activity, it was able to catalyze the formation of dimethylguanosine. Further, TRM1 specifically targeted the G26 position of human tRNA(Tyr). Mutation analysis showed that alterations in the conserved regions of the protein completely abrogated enzyme activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant tRNA Methyltransferase 1 Homolog (TRMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to tRNA Methyltransferase 1 Homolog (TRMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to tRNA Methyltransferase 1 Homolog (TRMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for tRNA Methyltransferase 1 Homolog (TRMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for tRNA Methyltransferase 1 Homolog (TRMT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant tRNA Methyltransferase 1 Homolog (TRMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to tRNA Methyltransferase 1 Homolog (TRMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to tRNA Methyltransferase 1 Homolog (TRMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for tRNA Methyltransferase 1 Homolog (TRMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for tRNA Methyltransferase 1 Homolog (TRMT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant tRNA Methyltransferase 1 Homolog (TRMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to tRNA Methyltransferase 1 Homolog (TRMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to tRNA Methyltransferase 1 Homolog (TRMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for tRNA Methyltransferase 1 Homolog (TRMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for tRNA Methyltransferase 1 Homolog (TRMT1) ELISA Kit Customized Service Offer
  1. "The human tRNA(m22G26)dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene."Nucleic Acids Res. 28:3445-3451(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]