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Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2)

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Tet Oncogene Family, Member 2

Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2)
CCC N131
HGNC 25941
MGI 2443298
PubMed 23222540
RGD 1311625
UniProt Q6N021
TET2 gene in bone marrow cells from 320 patients with myeloid cancers and identified TET2 defects in 15 (19%) of 81 patients with myelodysplastic syndromes, 24 (12%) of patients with myeloproliferative disorders, 5 (24%) of patients with secondary AML, and 2 (22%) of 9 patients with chronic myelomonocytic leukemia. The TET2 defects were present in hematopoietic stem cells and preceded the JAK2 V617F mutation in the 5 patients that were studied. In these individuals, TET2 mutations were found in most of their bone marrow cells and in various lineages of differentiation, including CD34+ progenitor cells, suggesting that TET2 mutations occur early during disease evolution. TET2 expression was shown to be elevated in hematopoietic cells with highest expression in granulocytes, consistent with a function in myelopoiesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 2 (TET2) ELISA Kit Customized Service Offer
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