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Keratin 75 (KRT75)

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K6HF; KB18; CK-75; K75; Cytokeratin-75; Keratin-6 hair follicle; Type-II keratin Kb18; Keratin, type II cytoskeletal 75

Keratin 75 (KRT75)
CCC N304
HGNC 24431
MGI 1923500
PubMed 17851587
RGD 1359576
UniProt O95678
Wiki KRT75
KRT75 is a member of the type II keratin family clustered on the long arm of chromosome 12. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae and loose anagen hair syndrome. Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Keratin 75 (KRT75) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Keratin 75 (KRT75) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Keratin 75 (KRT75) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Keratin 75 (KRT75) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 75 (KRT75) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Keratin 75 (KRT75) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Keratin 75 (KRT75) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Keratin 75 (KRT75) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Keratin 75 (KRT75) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 75 (KRT75) ELISA Kit Customized Service Offer
  1. "A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle."J. Invest. Dermatol. 111:955-962(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a 300 kbp region of human DNA containing the type II hair keratin."J. Invest. Dermatol. 114:464-472(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles."J. Invest. Dermatol. 121:1276-1282(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin."Physiol. Genomics 19:207-217(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of follicular sheath keratins in the normal nail with special reference to the morphological analysis of the distal nail unit."Am. J. Dermatopathol. 29:543-550(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study."Arch. Dermatol. 138:501-506(2002) [PubMed] [Europe PMC] [Abstract]
  9. "An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae."J. Invest. Dermatol. 122:652-657(2004) [PubMed] [Europe PMC] [Abstract]