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CD200 Receptor 1 (CD200R1)

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OX2R; HCRTR2; CD200R; MOX2R; MOX2 Receptor; Cell surface glycoprotein CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1

CD200 Receptor 1 (CD200R1)
CCC N341
HGNC 24235
MGI 1889024
PubMed 23082204
RGD 61837
UniProt Q8TD46
Wiki CD200R1
CD200R1 encodes a receptor for the OX-2 membrane glycoprotein. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. CD200R was expressed on human and murine mast cells. Engagement of CD200R by CD200 resulted in potent inhibition of mast cell degranulation and cytokine secretion.CD200R does not contain an immunoreceptor tyrosine-based inhibitory motif (ITIM) and thus represents a novel receptor that can be targeted in vivo to regulate mast cell-dependent pathologies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN341Hu01 Recombinant CD200 Receptor 1 (CD200R1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN341Hu01 Polyclonal Antibody to CD200 Receptor 1 (CD200R1) WB; IHC; ICC; IP.
MAN341Hu21 Monoclonal Antibody to CD200 Receptor 1 (CD200R1) WB; IHC; ICC; IP.
Assay Kits SEN341Hu ELISA Kit for CD200 Receptor 1 (CD200R1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN341Mu01 Recombinant CD200 Receptor 1 (CD200R1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN341Mu01 Polyclonal Antibody to CD200 Receptor 1 (CD200R1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for CD200 Receptor 1 (CD200R1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD200 Receptor 1 (CD200R1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CD200 Receptor 1 (CD200R1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CD200 Receptor 1 (CD200R1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CD200 Receptor 1 (CD200R1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CD200 Receptor 1 (CD200R1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD200 Receptor 1 (CD200R1) ELISA Kit Customized Service Offer
  1. "Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface."Am. J. Reprod. Immunol. 52:147-163(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200."J. Immunol. 171:3034-3046(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions."Adv. Immunol. 121:191-211(2014) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]