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Cell Death Inducing DFFA Like Effector C (CIDEC)

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CIDE-3; Fsp27; Fat-specific protein FSP27 homolog

Cell Death Inducing DFFA Like Effector C (CIDEC)
CCC N342
HGNC 24229
MGI 95585
PubMed 15893251
RGD 1562113
UniProt Q96AQ7
DNA fragmentation factor (DFF) induces the fragmentation of DNA associated with apoptosis. A novel family of cell death-inducing DFF45-like effectors (CIDEs), including CIDEC, can also promote apoptosis .
The deduced 238-amino acid protein has a predicted molecular mass of 26.8 kD and shares 44% and 38% identity with CIDEA and CIDEB, respectively. Northern blot analysis detected a 1.3-kb transcript mainly in small intestine, heart, colon, and stomach, with lower expression observed in brain, kidney, and liver. A 1.1-kb transcript was detected in placenta. The authors identified a 164-amino acid CIDEC isoform, which they called CIDE3-alpha, lacking the first N-terminal 74 amino acids. Immunofluorescence analysis localized CIDEC in a punctate manner to the cytosol.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN342Hu01 Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN342Hu01 Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN342Ra01 Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN342Ra01 Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family."Biochem. J. 370:195-203(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Fat-specific protein 27 regulates storage of triacylglycerol."J. Biol. Chem. 283:14355-14365(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Cidea is associated with lipid droplets and insulin sensitivity in humans."Proc. Natl. Acad. Sci. U.S.A. 105:7833-7838(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA."Am. J. Physiol. 297:E1395-E1413(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC." EMBO Mol. Med. 1:280-287(2009) [PubMed] [Europe PMC] [Abstract]
  9. "FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes."Biochem. Biophys. Res. Commun. 432:296-301(2013) [PubMed] [Europe PMC] [Abstract]