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Ribonuclease H2 Subunit C (RNASEH2C)

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AYP1; AGS3; Aicardi-Goutieres Syndrome 3; RNase H1 small subunit; Ribonuclease HI subunit C

Ribonuclease H2 Subunit C (RNASEH2C)
CCC N360
HGNC 24116
MGI 1915459
PubMed 23322642
UniProt Q8TDP1
RNASEH2Cencodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene.
The human RNASEH2A, RNASEH2B, and RNASEH2C genes interact with each other and form an enzymatic protein complex with RNase H2 activity. The complex was able to recognize and cleave a single ribonucleotide embedded in a DNA-DNA complex.Haplotype analysis suggested a founder effect. Affected members of a Pakistani family carried another homozygous mutation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonuclease H2 Subunit C (RNASEH2C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonuclease H2 Subunit C (RNASEH2C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonuclease H2 Subunit C (RNASEH2C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonuclease H2 Subunit C (RNASEH2C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease H2 Subunit C (RNASEH2C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonuclease H2 Subunit C (RNASEH2C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonuclease H2 Subunit C (RNASEH2C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonuclease H2 Subunit C (RNASEH2C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonuclease H2 Subunit C (RNASEH2C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease H2 Subunit C (RNASEH2C) ELISA Kit Customized Service Offer
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