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Melanoma Antigen Family D4 (MAGED4)

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MAGE1; MAGE-E1

Melanoma Antigen Family D4 (MAGED4)
CCC N391
HGNC 23793
PubMed 16082191
UniProt Q96JG8
414-amino acid isoform has a distinct 66-amino acid tail. The 2 long isoforms share 78.3% acid identity with MAGED1 over amino acids 421 to 600. Northern blot analysis detected expression of a 3-kb transcript in a human glioma cell line, primary glioblastoma, normal brain, and ovary only, with no expression in testis or placenta. RT-PCR analysis detected expression of the 2 long isoforms in glioma with the short isoform expressed in all tumor samples examined.
Expression of MAGED4 was upregulated in non-small cell lung cancers, but MAGED4 was not expressed in normal lung tissue. However, there was no significant difference in MAGED4 expression among different pathologic stages. The proliferative activity of tumor cells was significantly higher in tumors with high MAGED4 levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melanoma Antigen Family D4 (MAGED4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melanoma Antigen Family D4 (MAGED4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanoma Antigen Family D4 (MAGED4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melanoma Antigen Family D4 (MAGED4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melanoma Antigen Family D4 (MAGED4) ELISA Kit Customized Service Offer
  1. "MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma."Cancer Res. 61:4809-4814(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Structural characterization and chromosomal localization of the MAGE-E1 gene."Gene 277:129-137(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue."Cancer Biol. Ther. 4:943-948(2005) [PubMed] [Europe PMC] [Abstract]
  10. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]