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Sialyltransferase 7F (SIAT7F)

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ST6GALNAC6; ST6GALNACVI; ST6(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6

Sialyltransferase 7F (SIAT7F)
CCC N428
HGNC 23364
MGI 1355316
PubMed 17123352
UniProt Q969X2
Wiki ST6GALNAC6
ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions.The deduced 333-amino acid protein has an N-terminal cytoplasmic tail, a transmembrane region, and a long extracellular catalytic domain containing the conserved sialyl motifs L and S. St6GalNAc VI has 3 potential N-glycosylation sites. Northern blot analysis detected a 2.5-kb transcript in all mouse tissues examined, with highest levels in colon, brain, liver, and heart. A 7.5-kb transcript was also detected in colon.Mouse St6GalNAc VI showed alpha-2,6-sialyltransferase activity against the gangliosides GM1b, GT1b, and GD1a, forming GD1-alpha, GQ1b-alpha, and GT1a-alpha, respectively. No glycoproteins examined were used as acceptor substrates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 7F (SIAT7F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 7F (SIAT7F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 7F (SIAT7F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 7F (SIAT7F) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 7F (SIAT7F) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 7F (SIAT7F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 7F (SIAT7F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 7F (SIAT7F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 7F (SIAT7F) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 7F (SIAT7F) ELISA Kit Customized Service Offer
  1. "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides."J. Biol. Chem. 278:22787-22794(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of linkage-specific sequence motifs in sialyltransferases."Glycobiology 16:108-116(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers."Biochem. J. 402:459-470(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Carbohydrate antigen sialyl Lewis a - its pathophysiological significance and induction mechanism in cancer progression."Chang Gung Med. J. 30:189-209(2007) [PubMed] [Europe PMC] [Abstract]