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Malignant T-Cell Amplified Sequence 1 (MCTS1)

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MCT-1; Multiple copies T-cell malignancies

Malignant T-Cell Amplified Sequence 1 (MCTS1)
CCC N430
HGNC 23357
MGI 1916245
PubMed 23384686
RGD 1566390
UniProt Q9ULC4
MCT1 protein was not detected in leukemic cells from patients with chronic lymphocytic leukemia or in any healthy lymphoid tissue examined. Lymphoid cell lines overexpressing MCT1 exhibited increased growth and were protected from serum starvation-induced apoptosis. MCT1-overexpressing cells showed constitutively higher levels of phosphorylated AKT protein, especially under serum starvation.
The deduced 181-amino acid protein has a calculated molecular mass of 20 kD. MCT1 has 4 phosphorylation sites and a 58-amino acid C-terminal domain similar to the protein-protein interaction domain of cyclin H (CCNH). Northern blot analysis detected low ubiquitous expression of an MCT1 transcript smaller than 1 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Malignant T-Cell Amplified Sequence 1 (MCTS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Malignant T-Cell Amplified Sequence 1 (MCTS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Malignant T-Cell Amplified Sequence 1 (MCTS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Malignant T-Cell Amplified Sequence 1 (MCTS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Malignant T-Cell Amplified Sequence 1 (MCTS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Malignant T-Cell Amplified Sequence 1 (MCTS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Malignant T-Cell Amplified Sequence 1 (MCTS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Malignant T-Cell Amplified Sequence 1 (MCTS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Malignant T-Cell Amplified Sequence 1 (MCTS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Malignant T-Cell Amplified Sequence 1 (MCTS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Malignant T-Cell Amplified Sequence 1 (MCTS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Malignant T-Cell Amplified Sequence 1 (MCTS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Malignant T-Cell Amplified Sequence 1 (MCTS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Malignant T-Cell Amplified Sequence 1 (MCTS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Malignant T-Cell Amplified Sequence 1 (MCTS1) ELISA Kit Customized Service Offer
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  8. "Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies."Blood 102:297-302(2003) [PubMed] [Europe PMC] [Abstract]
  9. "MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells by promotion of angiogenesis and inhibition of apoptosis."Cancer Res. 65:10651-10656(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells."Oncogene 24:4956-4964(2005) [PubMed] [Europe PMC] [Abstract]
  11. "MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles."Cancer Res. 66:8994-9001(2006) [PubMed] [Europe PMC] [Abstract]
  12. "MCT-1 oncogene downregulates p53 and destabilizes genome structure in the response to DNA double-strand damage."DNA Repair 6:1319-1332(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage."Oncogene 26:2283-2289(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."Genes Dev. 24:1787-1801(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]