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Unc-51 Like Kinase 3 (ULK3)

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Serine/threonine-protein kinase ULK3

Unc-51 Like Kinase 3 (ULK3)
CCC N614
HGNC 19703
MGI 1918992
PubMed 20479155
RGD 1587417
UniProt Q6PHR2
The deduced 472-amino acid protein has a calculated molecular mass of 53 kD. ULK3 has an N-terminal 270-amino acid kinase domain followed by a microtubule-interacting domain. The kinase domain of ULK3 shares 38% identity with that of STK36 and 37% identity with that of Drosophila Fu, a kinase involved in hedgehog signaling.
Quantitative RT-PCR detected ULK3 expression in all tissues analyzed, with highest expression in fetal brain. In adult tissues, expression was highest in brain, liver, and kidney, with moderate expression in testis and adrenal gland, and low expression in heart, lung, stomach, thymus, prostate, and placenta. Within adult human brain regions, highest ULK3 expression was detected in hippocampus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-51 Like Kinase 3 (ULK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-51 Like Kinase 3 (ULK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-51 Like Kinase 3 (ULK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-51 Like Kinase 3 (ULK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-51 Like Kinase 3 (ULK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-51 Like Kinase 3 (ULK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-51 Like Kinase 3 (ULK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-51 Like Kinase 3 (ULK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-51 Like Kinase 3 (ULK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-51 Like Kinase 3 (ULK3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-51 Like Kinase 3 (ULK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-51 Like Kinase 3 (ULK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-51 Like Kinase 3 (ULK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-51 Like Kinase 3 (ULK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-51 Like Kinase 3 (ULK3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Autophagy mediates the mitotic senescence transition."Genes Dev. 23:798-803(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."Exp. Cell Res. 316:627-637(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway."J. Biol. Chem. 285:30079-30090(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]