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Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5)

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3-OST-5; HS3OST5; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5

Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5)
CCC N622
HGNC 19419
MGI 2441996
PubMed 24086445
RGD 1306379
UniProt Q8IZT8
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin. HS3ST5 expressed by transfected Chinese hamster ovary (CHO) cells displayed sulfotransferase activity toward heparan sulfate, generating at least three 3-O-sulfated disaccharides. HS3ST5 expressed by transfected Chinese hamster ovary (CHO) cells displayed sulfotransferase activity toward heparan sulfate, generating at least three 3-O-sulfated disaccharides. Transfection of HS3ST5 also rendered CHO cells susceptible to infection by herpes simplex virus-1, and HS3ST5-modified heparan sulfate bound the viral envelope protein, glycoprotein D. HS3ST5-modified heparan sulfate bound antithrombin, suggesting that HS3ST5 produces anticoagulant heparan sulfate.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heparan Sulfate-3-O-Sulfotransferase 5 (HS3ST5) ELISA Kit Customized Service Offer
  1. "Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1."J. Biol. Chem. 277:37912-37919(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide."J. Biol. Chem. 278:26780-26787(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The biosynthesis of anticoagulant heparan sulfate by the heparan sulfate 3-O-sulfotransferase isoform 5."Biochim. Biophys. Acta 1671:34-43(2004) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Engineering sulfotransferases to modify heparan sulfate."Nat. Chem. Biol. 4:200-202(2008) [PubMed] [Europe PMC] [Abstract]