Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1)

The deduced 522-amino acid protein contains an N-terminal signal sequence, followed by 10 extracellular LRRs flanked by cysteine-rich domains, a transmembrane region, and an intracellular tail. LRRTM1 has 3 N-glycosylation sites, several putative phosphorylation sites, and a C terminus that ends in the sequence ECEV, which is a characteristic of LRRTM family members. Orthologs of LRRTM1 were detected in databases derived from several vertebrate species but not in databases derived from Drosophila or C. elegans. RT-PCR analysis of human tissues detected highest LRRTM1 expression in salivary gland and in brain, including hippocampus, thalamus, caudate nucleus, corpus callosum, and amygdala. Expression was intermediate in cerebellum, small intestine, spinal cord, stomach, testis, and uterus.