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Serine/Threonine Kinase 11 Interacting Protein (STK11IP)

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LIP1; LKB1IP; STK11IP1; LKB1 Interacting Protein

Serine/Threonine Kinase 11 Interacting Protein (STK11IP)
CCC N651
HGNC 19184
MGI 1918978
PubMed 14985505
RGD 1305046
UniProt Q8N1F8
LIP1 appears to be a cytoplasmically located protein, whereas LKB1 is predominantly nuclear. When LKB1 and LIP1 were coexpressed in vitro, the proportion of cytoplasmic LKB1 dramatically increased, suggesting that LIP1 may regulate LKB1 function by controlling its subcellular localization.
Ectopic expression of both LKB1 and LIP1 in Xenopus embryos induced a secondary body axis, resembling the effects of ectopic expression of TGF-beta superfamily members and their downstream effectors. Furthermore, LIP1 interacted with the TGF-beta-regulated transcription factor SMAD4, forming a LKB1-LIP1-SMAD4 ternary complex. Since SMAD4 mutations give rise to juvenile intestinal polyposis syndrome

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 11 Interacting Protein (STK11IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 11 Interacting Protein (STK11IP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 11 Interacting Protein (STK11IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 11 Interacting Protein (STK11IP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 11 Interacting Protein (STK11IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 11 Interacting Protein (STK11IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 11 Interacting Protein (STK11IP) ELISA Kit Customized Service Offer
  1. "LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1."Hum. Mol. Genet. 10:2869-2877(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2."Cytogenet. Genome Res. 97:171-178(2002) [PubMed] [Europe PMC] [Abstract]