Keratin Associated Protein 11-1 (KRTAP11-1)

From a cDNA library of mouse skin, Huh et al. (1994) isolated a hair-follicle-specific gene which they designated Hacl1. The gene was expressed specifically in skin, and its mRNA level was correlated with the active state of hair follicles in developmental and regenerative processes of hair. Its mRNA was approximately 1 kb. The deduced amino acid sequence showed 6 direct repeats of a decapeptide on the C-terminal side. In situ hybridization showed that the gene is expressed specifically in the keratogenous zone of the cortical cells of the hair shaft.

By genomic sequence analysis, Pruett et al. (2004) mapped the mouse Krtap11-1 gene to distal chromosome 16 and the human KRTAP11-1 gene to chromosome 21q22.11, a region of conserved linkage.