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Fifth Ewing Variant (FEV)

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Pet-1; PC12 ETS domain-containing transcription factor 1

Fifth Ewing Variant (FEV)
CCC N728
HGNC 18562
MGI 2449712
PubMed 19707175
RGD 628860
UniProt Q99581
FEV belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations.
In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fifth Ewing Variant (FEV) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fifth Ewing Variant (FEV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fifth Ewing Variant (FEV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fifth Ewing Variant (FEV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fifth Ewing Variant (FEV) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fifth Ewing Variant (FEV) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fifth Ewing Variant (FEV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fifth Ewing Variant (FEV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fifth Ewing Variant (FEV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fifth Ewing Variant (FEV) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fifth Ewing Variant (FEV) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fifth Ewing Variant (FEV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fifth Ewing Variant (FEV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fifth Ewing Variant (FEV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fifth Ewing Variant (FEV) ELISA Kit Customized Service Offer
  1. "A new member of the ETS family fused to EWS in Ewing tumors."Oncogene 14:1159-1164(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain."Oncogene 22:3319-3329(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The Ets transcription factor Fev is specifically expressed in the human central serotonergic neurons."Neurosci. Lett. 357:215-218(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain."Synapse 57:223-228(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma."Cell Cycle 5:2753-2759(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Sudden infant death syndrome: rare mutation in the serotonin system FEV gene."Pediatr. Res. 62:180-182(2007) [PubMed] [Europe PMC] [Abstract]