Proline Rich Membrane Anchor 1 (PRIMA1)

As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. collagen Q (ColQ) anchors AChE at the neuromuscular junction.PRiMA (proline-rich membrane anchor) encoding the AChE anchor in mammalian brain.

PRiMA is able to organize AChE into tetramers and to anchor them at the surface of transfected cells. AChE is actually anchored in neural cell membranes through its interaction with PRiMA. PRiMA anchors AChE in mammalian brain and muscle cell membranes. Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers.