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Down Regulated In Metastasis (DRIM)

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NNP73; UTP20,Small Subunit(SSU)Processome Component,Homolog; Protein Key-1A6; Novel nucleolar protein 73

Down Regulated In Metastasis (DRIM)
CCC N811
HGNC 17897
MGI 1917933
RGD 1560606
UniProt O75691
UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A) protein complex (U3 snoRNP) and is involved in 18S rRNA processing.
The deduced 2,785-amino acid protein contains several HEAT repeats of about 40 amino acids each throughout its sequence. Northern blot analysis detected strong expression of a 10-kb transcript in heart, skeletal muscle, pancreas, testis, and ovary. Expression was moderate in placenta, spleen, thymus, prostate, small intestine, appendix, and fetal liver, and very low in brain, colon, bone marrow, and normal mammary gland. No expression was detected in lung, liver, kidney, and peripheral blood leucocytes. UTP20 was also expressed in several divergent human tumor cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Down Regulated In Metastasis (DRIM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Down Regulated In Metastasis (DRIM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Down Regulated In Metastasis (DRIM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Down Regulated In Metastasis (DRIM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Down Regulated In Metastasis (DRIM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Down Regulated In Metastasis (DRIM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Down Regulated In Metastasis (DRIM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Down Regulated In Metastasis (DRIM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Down Regulated In Metastasis (DRIM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Down Regulated In Metastasis (DRIM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Down Regulated In Metastasis (DRIM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Down Regulated In Metastasis (DRIM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Down Regulated In Metastasis (DRIM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Down Regulated In Metastasis (DRIM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Down Regulated In Metastasis (DRIM) ELISA Kit Customized Service Offer
  1. "Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis."Anticancer Res. 18:1409-1421(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Directed proteomic analysis of the human nucleolus."Curr. Biol. 12:1-11(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  5. "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential."Biochem. Biophys. Res. Commun. 334:884-890(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Mapping nucleolar localization sequences of 1A6/DRIM."FEBS Lett. 580:1405-1410(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing."Biochim. Biophys. Acta 1773:863-868(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]