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CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1)

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Threonylcarbamoyladenosine tRNA methylthiotransferase; tRNA-t(6)A37 methylthiotransferase

CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1)
CCC N991
HGNC 21050
MGI 1921765
PubMed 22344221
RGD 1310246
UniProt Q5VV42
Wiki CDKAL1
CDKAL1 is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibility to type 2 diabetes.
Zeggini et al. (2007) stated that the CDKAL1 gene encodes a 579-residue, 65-kD protein that shares considerable domain and amino acid homology with CDK5RAP1, an inhibitor of CDK5 activation. They detected CDKAL1 mRNA in human pancreatic islet and skeletal muscle by RT-PCR. Using quantitative RT-PCR analysis of a panel of RNA samples from human tissues and cells, Scott et al. (2007) detected highest CDKAL1 expression in skeletal muscle and brain cells, as well as in 293T and HepG2 cells.The CDKAL1 gene maps to chromosome 6p22.3

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 Regulatory Subunit Associated Protein 1 Like Protein 1 (CDKAL1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A variant in CDKAL1 influences insulin response and risk of type 2 diabetes." Nat. Genet. 39:770-775(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels." Science 316:1331-1336(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA."J. Biol. Chem. 285:28425-28433(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells."J. Biol. Chem. 287:41808-41819(2012) [PubMed] [Europe PMC] [Abstract]