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Rho GTPase Activating Protein 18 (ARHGAP18)

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MacGAP

Rho GTPase Activating Protein 18 (ARHGAP18)
CCC N997
HGNC 21035
MGI 1921160
PubMed 23468526
RGD 1305053
UniProt Q8N392
Wiki ARHGAP18
ARHGAP18 belongs to a family of Rho GTPase-activating proteins that modulate cell signaling. By genomic sequence analysis, Potkin et al. (2009) mapped the ARHGAP18 gene to chromosome 6q22-q24.
Myosin was involved in Rac control of directionality but not in Rac-induced protrusion, whereas PAK was required for Rac-induced protrusion. PA-Rac1 was used to elucidate Rac regulation of RhoA in cell motility. Rac and Rho coordinate cytoskeletal behaviors with seconds and submicrometer precision. Rac was shown to inhibit RhoA in mouse embryonic fibroblasts, with inhibition modulated at protrusions and ruffles. A PA-Rac crystal structure and modeling revealed LOV-Rac interactions that will facilitate extension of this photoactivation approach to other proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho GTPase Activating Protein 18 (ARHGAP18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho GTPase Activating Protein 18 (ARHGAP18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho GTPase Activating Protein 18 (ARHGAP18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho GTPase Activating Protein 18 (ARHGAP18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho GTPase Activating Protein 18 (ARHGAP18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho GTPase Activating Protein 18 (ARHGAP18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho GTPase Activating Protein 18 (ARHGAP18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho GTPase Activating Protein 18 (ARHGAP18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho GTPase Activating Protein 18 (ARHGAP18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho GTPase Activating Protein 18 (ARHGAP18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho GTPase Activating Protein 18 (ARHGAP18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho GTPase Activating Protein 18 (ARHGAP18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho GTPase Activating Protein 18 (ARHGAP18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho GTPase Activating Protein 18 (ARHGAP18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho GTPase Activating Protein 18 (ARHGAP18) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Uterus.
  4. "A protein interaction framework for human mRNA degradation."Genome Res. 14:1315-1323(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]