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HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1)

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HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1)
CCC N998
HGNC 21033
MGI 2446110
PubMed 22614015
RGD 1306114
UniProt Q8IYU2
HACE1 has ubiquitin ligase activity, utilizing UBCH7 (UBE2L3) as a candidate partner E2 enzyme. HACE1 associated with ubiquitinated proteins and components of the 26S proteasomal complex, indicating that at least some proteins targeted for ubiquitination by HACE1 are degraded by the proteasome.
The predicted 909-amino acid protein has a calculated molecular mass of about 103 kD and contains 6 N-terminal ankyrin repeats and a C-terminal HECT domain.By subcellular fractionation and immunofluorescence studies in NIH3T3 fibroblasts, the authors found that HACE1 localized primarily to endoplasmic reticulum and the cytoplasm with small amounts of endogenous protein present in other fractions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) CLIA Kit Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney."Hum. Mol. Genet. 13:2061-2074(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers."Nat. Med. 13:1060-1069(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene."J. Med. Genet. 47:342-347(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1."Dev. Cell 21:959-965(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle."Nat. Commun. 2:501-501(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]