4-Hydroxytestosterone (4-OHT)

4-Hydroxytestosterone (4,17beta-dihydroxy-4-androstene-3-one) is an anabolic steroid. 4-OHT has moderate anabolic, mild androgenic, and anti-aromatic properties and is similar to the steroid clostebol.

4-Hydroxyandrost-4-ene-3,17-dione is a second generation, irreversible aromatase inhibitor and commonly used as anti breast cancer medication for postmenopausal women. 4-Hydroxytestosterone is advertised as anabolic steroid and does not have any therapeutic indication. Both substances are prohibited in sports by the World Anti-Doping Agency, and, due to a considerable increase of structurally related steroids with anabolic effects offered via the internet, the metabolism of two representative candidates was investigated.