Zolazepam was discovered by a team at Parke-Davis in the 1960s.(Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the alpha-2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for. It is around 4 times the potency of diazepam (0.32mg/Kg vs 1.2mg/Kg in animal models) but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast. Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be superior to ketamine because of reduced side-effects.[3][4] A 1:1 mixture of Zolazepam and tiletamine is sold under the name Telazol.
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