Carbofuran is one of the most toxic carbamate pesticides. It is used to control insects in a wide variety of field crops, including potatoes, corn and soybeans. It is a systemic insecticide, which means that the plant absorbs it through the roots, and from here the plant distributes it throughout its organs where insecticidal concentrations are attained. Carbofuran also has contact activity against pests. Carbofuran has one of the highest acute toxicities to humans of any insecticide widely used on field crops (only aldicarb and parathion are more toxic). A quarter teaspoon (1 mL) can be fatal. Most carbofuran is applied by commercial applicators using closed systems with engineered controls so there is no exposure to it in preparation. Since its toxic effects are due to its activity as a cholinesterase inhibitor it is considered a neurotoxic pesticide.