Fustin is a flavanonol, a type of flavonoid. It can be found in young fustic (Cotinus coggygria) and in the lacquer tree(Toxicodendron vernicifluum, aka Rhus verniciflua).Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.Fustin possesses stereoisomers : (−)-Fustin and (+)-Fustin. Natural flavonoids ameliorate amyloid-beta peptide (Abeta)-induced neurotoxicity. Repeated treatment with fustin significantly attenuated Abeta (1-42)-induced conditioned fear and passive avoidance behaviors. This effect was comparable to that of EGb761, a standard extract of ginkgo. Fustin treatment significantly prevented decreases in acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene expression induced by Abeta (1-42). Fustin also consistently suppressed increases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Abeta (1-42).
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