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Myeloid Derived Growth Factor (MYDGF)

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SF20; IL25; IL27w; C19orf10; Interleukin 27 Working Designation; Interleukin-25; Stromal cell-derived growth factor SF20

Myeloid Derived Growth Factor (MYDGF)
CCC P027
HGNC 16948
MGI 2156020
RGD 1589603
UniProt Q969H8
The deduced 173-amino acid protein contains 2 O-glycosylation sites and several potential phosphorylation sites. There was evidence of 2 additional splice variants. The human and mouse C19ORF10 proteins share 91% sequence identity. Immunohistochemistry analyses of recombinant C19ORF10 in cultured FLSs and in synovial tissue sections from patients with rheumatoid arthritis (RA) or osteoarthritis (OA) revealed intracellular staining consistent with localization in the endoplasmic reticulum/Golgi apparatus. Sections of RA and OA synovia expressed similar patterns of C19ORF10 distribution with perivascular and synovial lining staining. Double-staining in situ analysis suggested that fibroblast-like synovial cells produced C19ORF10, whereas macrophages, B cells, or T cells produced little or none of this protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid Derived Growth Factor (MYDGF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid Derived Growth Factor (MYDGF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid Derived Growth Factor (MYDGF) Polyclonal Antibody Customized Service Offer
Assay Kits SEP027Hu ELISA Kit for Myeloid Derived Growth Factor (MYDGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP027Mu01 Recombinant Myeloid Derived Growth Factor (MYDGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Myeloid Derived Growth Factor (MYDGF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid Derived Growth Factor (MYDGF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid Derived Growth Factor (MYDGF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid Derived Growth Factor (MYDGF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid Derived Growth Factor (MYDGF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid Derived Growth Factor (MYDGF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid Derived Growth Factor (MYDGF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid Derived Growth Factor (MYDGF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid Derived Growth Factor (MYDGF) ELISA Kit Customized Service Offer
  1. "SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation."J. Immunol. 167:6338-6347(2001) [PubMed] [Europe PMC] [Abstract]
  2. ErratumJ. Immunol. 170:1593-1593(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
  6. "The identification and characterization of a novel protein, c19orf10, in the synovium."Arthritis Res. Ther. 9:R30-R30(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction."Nat. Med. 21:140-149(2015) [PubMed] [Europe PMC] [Abstract]