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Proteasome 26S Subunit, Non ATPase 14 (PSMD14)

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POH1; pad1; Rpn11; 26S proteasome non-ATPase regulatory subunit 14

Proteasome 26S Subunit, Non ATPase 14 (PSMD14)
CCC P037
HGNC 16889
MGI 1913284
PubMed 19732767
RGD 1594532
UniProt O00487
Wiki PSMD14
PSMD14 is a component of the 26S proteasome, a multiprotein complex that degrades proteins targeted for destruction by the ubiquitin pathway.The predicted 310-amino acid POH1 protein shares 68% identity with fission yeast Pad1 and is also related to JAB1 and the S12/p40 component of the 26S proteasome regulatory subunit (PSMD7). Northern blot analysis detected a 1.7-kb POH1 transcript in a wide variety of human tissues, with the highest levels in heart and skeletal muscle.POH1 can substitute fully for Pad1(+) and induce AP1-dependent drug resistance in fission yeast. Further, transient overproduction of POH1 in COS-1 cells induced a distinctive pattern of multidrug resistance in mammalian cells and moderate resistance to ultraviolet light.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 14 (PSMD14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 14 (PSMD14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 14 (PSMD14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 14 (PSMD14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 14 (PSMD14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 14 (PSMD14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 14 (PSMD14) ELISA Kit Customized Service Offer
  1. "Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit."J. Biol. Chem. 272:30470-30475(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. , Submitted (MAR-2007) to UniProtKB
  5. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  7. "K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1."EMBO J. 28:621-631(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome."J. Biol. Chem. 284:15246-15254(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response."EMBO J. 31:3918-3934(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]