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Sulfiredoxin 1 (SRXN1)

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Npn3; SRX1; C20orf139

Sulfiredoxin 1 (SRXN1)
CCC P133
HGNC 16132
MGI 104971
PubMed 11076863
RGD 1307332
UniProt Q9BYN0
Wiki SRXN1
Sulfiredoxin-1 (Srx1) catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation. Nrf2, a transcription factor known to influence susceptibility to pulmonary diseases, upregulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs of mice. Disruption of Nrf2 signaling by genetic knockout in mice or RNAi in cells downregulated the expression of Srx1. In silico analysis of the 5'-promoter-flanking region of Srx1 identified multiple antioxidant-response elements (AREs) that are highly conserved. Reporter and chromatin-immunoprecipitation assays demonstrated that ARE1 at -228 is critical for the Nrf2-mediated response.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sulfiredoxin 1 (SRXN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sulfiredoxin 1 (SRXN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sulfiredoxin 1 (SRXN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sulfiredoxin 1 (SRXN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sulfiredoxin 1 (SRXN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sulfiredoxin 1 (SRXN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sulfiredoxin 1 (SRXN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sulfiredoxin 1 (SRXN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sulfiredoxin 1 (SRXN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sulfiredoxin 1 (SRXN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sulfiredoxin 1 (SRXN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sulfiredoxin 1 (SRXN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sulfiredoxin 1 (SRXN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sulfiredoxin 1 (SRXN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sulfiredoxin 1 (SRXN1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
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  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine."J. Biol. Chem. 279:50994-51001(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins."J. Biol. Chem. 280:3125-3128(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of human sulfiredoxin (SRX)."Submitted (FEB-2004) to the PDB data bank
  10. "Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin."Biochemistry 44:8634-8642(2005) [PubMed] [Europe PMC] [Abstract]