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LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2)

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PINCH2; LIM-like protein 2; Particularly interesting new Cys-His protein 2

LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2)
CCC P139
HGNC 16084
MGI 2385067
PubMed 12167643
RGD 1305273
UniProt Q7Z4I7
LIMS2 is a focal adhesion protein that associates with integrin-linked kinase (ILK), a multidomain protein that mediates multiple protein-protein interactions at adhesion sites between cells and the extracellular matrix (ECM).
LIMS2 forms a complex with ILK and that the interaction requires the first LIM domain (LIM1) of LIMS2. A LIM1-deletion mutant, unlike wildtype LIMS2, was incapable of localizing to cell-ECM contact sites, suggesting that ILK binding is required for this association. LIMS2-ILK and LIMS1-ILK interactions are mutually exclusive. Overexpression of LIMS2 in a mouse myoblast cell line inhibited the interaction between LIMS1 and ILK and reduced cell spreading and migration in rat embryo fibroblasts.LIMS2 shares 82% amino acid identity with LIMS1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM And Senescent Cell Antigen Like Domains Protein 2 (LIMS2) ELISA Kit Customized Service Offer
  1. "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration."J. Biol. Chem. 277:38328-38338(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase."J. Struct. Biol. 170:157-163(2010) [PubMed] [Europe PMC] [Abstract]