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Mitochondrial Ribosomal Protein S4 (MRPS4)

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BRMS2; C15orf12; IMP3,U3 Small Nucleolar Ribonucleoprotein Homolog

Mitochondrial Ribosomal Protein S4 (MRPS4)
CCC P248
HGNC 14497
MGI 1916119
RGD 1306825
UniProt Q9NV31
IMP3 forms a ternary complex with IMP4 and MPP10 (MPHOSPHO10) that interacts with U3 small nucleolar RNA (snoRNA), which is required for the early cleavage steps in pre-rRNA processing .
The deduced 180-amino acid protein has a calculated molecular mass of 21.8 kD and shares approximately 50% identity with yeast Imp3. IMP3 contains a predicted coiled-coil domain and an S4 domain. Fluorescence microscopy localized IMP3 to the nucleoli in transfected Hep2 cells.Glycerol gradient cosedimentation and GST pull-down studies showed that IMP3, IMP4, and MPP10 form a heterotrimeric protein complex. Analysis of deletion mutants showed that both the IMP3 S4 domain and coiled-coil region are required for interaction with MPP10 amino acids 457 to 565.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP248Hu01 Recombinant Mitochondrial Ribosomal Protein S4 (MRPS4) Positive Control; Immunogen; SDS-PAGE; WB.
EPP248Hu61 Eukaryotic Mitochondrial Ribosomal Protein S4 (MRPS4) Positive Control; Immunogen; SDS-PAGE; WB.
APP248Hu61 Active Mitochondrial Ribosomal Protein S4 (MRPS4) Cell culture; Activity Assays.
Antibodies MAP248Hu21 Monoclonal Antibody to Mitochondrial Ribosomal Protein S4 (MRPS4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mitochondrial Ribosomal Protein S4 (MRPS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Ribosomal Protein S4 (MRPS4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Ribosomal Protein S4 (MRPS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Ribosomal Protein S4 (MRPS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Ribosomal Protein S4 (MRPS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Ribosomal Protein S4 (MRPS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Ribosomal Protein S4 (MRPS4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Ribosomal Protein S4 (MRPS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Ribosomal Protein S4 (MRPS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Ribosomal Protein S4 (MRPS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Ribosomal Protein S4 (MRPS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Ribosomal Protein S4 (MRPS4) ELISA Kit Customized Service Offer
  1. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes."Nucleic Acids Res. 31:1877-1887(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure of the S4 domain of U3 small nucleolar ribonucleoprotein protein IMP3 homolog."Submitted (NOV-2005) to the PDB data bank