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Autism Susceptibility Candidate 2 (AUTS2)

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FBRSL2

Autism Susceptibility Candidate 2 (AUTS2)
CCC P290
HGNC 14262
MGI 1919847
PubMed 12160723
RGD 1309972
UniProt Q8WXX7
The predicted 1,259-amino acid protein contains 2 proline-rich domains and regions that share homology with the dwarfin family consensus sequence and with topoisomerase. It has a PY motif, several putative phosphorylation sites and N-myristoylation sites, and 2 putative N-glycosylation sites.
The AUTS2 protein shares 93% amino acid identity with its murine homolog. Northern blot analysis detected strong expression of 7.5- and 8.0-kb transcripts in fetal and adult brain. KIAA0442 was also strongly expressed in skeletal muscle and kidney, with lower levels in placenta, lung, and leukocytes. In fetal brain, KIAA0442 was expressed in frontal, parietal, and temporal lobes, but not in the occipital lobe.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autism Susceptibility Candidate 2 (AUTS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autism Susceptibility Candidate 2 (AUTS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autism Susceptibility Candidate 2 (AUTS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autism Susceptibility Candidate 2 (AUTS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autism Susceptibility Candidate 2 (AUTS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autism Susceptibility Candidate 2 (AUTS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autism Susceptibility Candidate 2 (AUTS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autism Susceptibility Candidate 2 (AUTS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autism Susceptibility Candidate 2 (AUTS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autism Susceptibility Candidate 2 (AUTS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autism Susceptibility Candidate 2 (AUTS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autism Susceptibility Candidate 2 (AUTS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autism Susceptibility Candidate 2 (AUTS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autism Susceptibility Candidate 2 (AUTS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autism Susceptibility Candidate 2 (AUTS2) ELISA Kit Customized Service Offer
  1. "Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins."Genomics 80:129-134(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus." Am. J. Hum. Genet. 92:210-220(2013) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]