F-Box And Leucine Rich Repeat Protein 16 (FBXL16)

Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains . Jin et al. (2004) reported that the human FBXL16 protein contains an F box in its N-terminal half, followed by a spacer, 8 tandemly arrayed leucine-rich repeats, another spacer, and a C-terminal leucine-rich repeat.By sequence analysis, Daniels et al. (2001) mapped the FBXL16 gene, which they called C16ORF22, to a gene-rich region of chromosome 16p13.3.Jin et al. (2004) stated that the mouse Fbxl16 gene maps to chromosome 17A3.3.