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CCR4 NOT Transcription Complex Subunit 6 (CNOT6)

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CCR4; CCR4a; CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase

CCR4 NOT Transcription Complex Subunit 6 (CNOT6)
CCC P308
HGNC 14099
MGI 2144529
PubMed 21233283
RGD 1310783
UniProt Q9ULM6
Wiki CNOT6
CNOT6 contains 575 amino acids. RT-PCR ELISA detected variable expression in all fetal and adult tissues and specific brain regions examined. Highest expression was in adult brain, testis, ovary, spinal cord, and caudate nucleus, and lowest expression was in pancreas and spleen. CNOT6 augments the ligand-dependent transcriptional activation of a wide variety of nuclear receptors, including RARA, THRA, RXRA, ESR1, and GCCR, through an NIF1 coactivator complex. siRNA-mediated silencing of endogenous CNOT6 resulted in a marked decrease in nuclear receptor activation as well as attenuated stimulation of RARA target genes, including SOX9 and HOXA1. siRNA knockdown of NIF1, with which CNOT6 associates in vivo, blocked the ligand-dependent potentiating effect of CNOT6.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 6 (CNOT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 6 (CNOT6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 6 (CNOT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 6 (CNOT6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 6 (CNOT6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 6 (CNOT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 6 (CNOT6) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding."BMC Genomics 2:9-9(2001) [PubMed] [Europe PMC] [Abstract]
  4. "CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase."EMBO J. 21:1414-1426(2002) [PubMed] [Europe PMC] [Abstract]
  5. "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant."Genes Dev. 18:2010-2023(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1."J. Biol. Chem. 283:6806-6816(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Human Ccr4-Not complexes contain variable deadenylase subunits."Biochem. J. 422:443-453(2009) [PubMed] [Europe PMC] [Abstract]
  8. "CCR4-NOT deadenylates mRNA associated with complexes in human cells."Mol. Cell. Biol. 30:1486-1494(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence."Mol. Biol. Cell 22:748-758(2011) [PubMed] [Europe PMC] [Abstract]