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Kidney Anion Exchanger Adaptor Protein (Kanadaptin)

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HLC3; SLC4A1AP; Solute Carrier Family 4(Anion Exchanger),Member 1; Adaptor Protein; Lung Cancer Oncogene 3

Kidney Anion Exchanger Adaptor Protein (Kanadaptin)
CCC P361
HGNC 13813
MGI 1196608
RGD 1307080
UniProt Q9BWU0
Kanadaptin binds to the cytoplasmic domain of the kidney isoform of erythroid band 3 (AE1) but not to the erythroid isoform or to ankyrin. Kanadaptin contains 507 amino acids and is proline-rich. Northern blot analysis revealed that in mouse the gene is widely expressed at a low level. Immunolocalization demonstrated that the protein is cytosolic, with a higher concentration in the region of plasma membranes, especially apical membranes.the expression of kanadaptin in mouse kidney is restricted to the collecting tubule. In the intercalated cells of that segment, it colocalizes with kidney AE1 (kAE1) only when the latter is in intracellular vesicles and not when it has been delivered to the basolateral membrane. Kanadaptin may be part of the machinery that targets kAE1 to the basolateral membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kidney Anion Exchanger Adaptor Protein (Kanadaptin) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kidney Anion Exchanger Adaptor Protein (Kanadaptin) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kidney Anion Exchanger Adaptor Protein (Kanadaptin) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kidney Anion Exchanger Adaptor Protein (Kanadaptin) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kidney Anion Exchanger Adaptor Protein (Kanadaptin) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kidney Anion Exchanger Adaptor Protein (Kanadaptin) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kidney Anion Exchanger Adaptor Protein (Kanadaptin) ELISA Kit Customized Service Offer
  1. "Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells."Mol. Membr. Biol. 21:395-402(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of a FHA domain of kanadaptin (SLC4A1AP) from Homo sapiens at 1.55 A resolution."Submitted (OCT-2012) to the PDB data bank