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ATPase Class I Type 8B4 (ATP8B4)

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ATPIM; P4-ATPase flippase complex alpha subunit ATP8B4; Probable phospholipid-transporting ATPase IM

ATPase Class I Type 8B4 (ATP8B4)
CCC P393
HGNC 13536
MGI 1859664
PubMed 23087808
UniProt Q8TF62
ATP8B4 belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another.
By sequencing clones obtained from a size-fractionated adult amygdala cDNA library, Nagase et al. (2001) cloned ATP8B4, which they designated KIAA1939. The 3-prime UTR of the transcript contains repetitive elements, and the deduced protein contains 1,082 amino acids. RT-PCR ELISA detected intermediate expression in all tissues and specific brain regions examined, with highest expression in spleen, ovary, and fetal liver. Lowest expression was in pancreas, skeletal muscle, and adult and fetal brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Class I Type 8B4 (ATP8B4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Class I Type 8B4 (ATP8B4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Class I Type 8B4 (ATP8B4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Class I Type 8B4 (ATP8B4) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Class I Type 8B4 (ATP8B4) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases."J. Biol. Chem. 285:40088-40096(2010) [PubMed] [Europe PMC] [Abstract]
  5. "CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery."J. Biol. Chem. 285:40562-40572(2010) [PubMed] [Europe PMC] [Abstract]