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ATPase Class I Type 8B2 (ATP8B2)

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ATPID; P4-ATPase flippase complex alpha subunit ATP8B2; Phospholipid-transporting ATPase ID

ATPase Class I Type 8B2 (ATP8B2)
CCC P395
HGNC 13534
MGI 1859660
PubMed 12880872
RGD 1597731
UniProt P98198
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified.
ATP8B2 is 53% identical to FIC1 (ATP8B1), which is associated with cholestasis. RT-PCR analysis detected wide expression, with highest levels in amygdala, followed by cerebellum, caudate nucleus, subthalamic nucleus, ovary, whole brain, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Class I Type 8B2 (ATP8B2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Class I Type 8B2 (ATP8B2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Class I Type 8B2 (ATP8B2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Class I Type 8B2 (ATP8B2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Class I Type 8B2 (ATP8B2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Class I Type 8B2 (ATP8B2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Class I Type 8B2 (ATP8B2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Class I Type 8B2 (ATP8B2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Class I Type 8B2 (ATP8B2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Class I Type 8B2 (ATP8B2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Class I Type 8B2 (ATP8B2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Class I Type 8B2 (ATP8B2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Class I Type 8B2 (ATP8B2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Class I Type 8B2 (ATP8B2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Class I Type 8B2 (ATP8B2) ELISA Kit Customized Service Offer
  1. "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body."Biochim. Biophys. Acta 1633:127-131(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases."J. Biol. Chem. 285:40088-40096(2010) [PubMed] [Europe PMC] [Abstract]
  8. "CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery."J. Biol. Chem. 285:40562-40572(2010) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]