Basic Charge, Y-Linked 2 (BPY2)

BPY2 is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic. The predicted 106-amino acid BPY2 protein has a calculated pI of 10.0. It is unrelated to BPY1. BPY1 and BPY2 are 2 of 7 novel genes that appear to exist in multiple copies on the Y chromosome and are expressed specifically in testis. the selective advantage conferred by the NRY's retention and amplification of male fertility factors accounts for the multitude of testis-specific gene families there.