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Vacuolar Protein Sorting 35 (VPS35)

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MEM3; Maternal-embryonic 3; Vesicle protein sorting 35; Vacuolar protein sorting-associated protein 35

Vacuolar Protein Sorting 35 (VPS35)
CCC P402
HGNC 13487
MGI 1890467
PubMed 21763483
RGD 1589784
UniProt Q96QK1
Wiki VPS35
VPS35 is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. The SSEC-26 transcript was abundant in the unfertilized egg and also actively transcribed from the newly formed zygotic genome. On the basis of its expression in eggs and embryos, this mouse gene was named Mem3 (maternal-embryonic-3). The deduced amino acid sequence of Mem3 resembles that of the yeast VPS35 protein in 2 separate domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 35 (VPS35) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 35 (VPS35) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 35 (VPS35) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 35 (VPS35) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 35 (VPS35) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 35 (VPS35) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 35 (VPS35) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 35 (VPS35) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 35 (VPS35) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 35 (VPS35) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 35 (VPS35) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 35 (VPS35) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 35 (VPS35) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 35 (VPS35) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 35 (VPS35) ELISA Kit Customized Service Offer
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  2. "Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21."Genomics 70:253-257(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."Mol. Biol. Cell 11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor."J. Cell Biol. 165:123-133(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor."Nat. Cell Biol. 6:763-769(2004) [PubMed] [Europe PMC] [Abstract]
  9. "EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval."Traffic 8:1873-1886(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5."J. Cell Sci. 122:2371-2382(2009) [PubMed] [Europe PMC] [Abstract]
  11. "GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer."Nature 459:1085-1090(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics."J. Cell Sci. 123:3703-3717(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1."J. Cell Sci. 123:756-766(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion."Nat. Cell Biol. 13:914-923(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35."Biochem. J. 442:209-220(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer."Mol. Biol. Cell 23:2352-2361(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer."Biol. Cell 105:191-207(2013) [PubMed] [Europe PMC] [Abstract]
  20. "Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination."Cell 152:1051-1064(2013) [PubMed] [Europe PMC] [Abstract]
  21. "A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport."Nat. Cell Biol. 15:461-471(2013) [PubMed] [Europe PMC] [Abstract]
  22. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "A mechanism for retromer endosomal coat complex assembly with cargo."Proc. Natl. Acad. Sci. U.S.A. 111:267-272(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation."Curr. Biol. 24:1670-1676(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy."Nat. Commun. 5:3828-3828(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Functional architecture of the retromer cargo-recognition complex."Nature 449:1063-1067(2007) [PubMed] [Europe PMC] [Abstract]
  28. "VPS35 mutations in Parkinson disease." Am. J. Hum. Genet. 89:162-167(2011) [PubMed] [Europe PMC] [Abstract]
  29. "A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease." Am. J. Hum. Genet. 89:168-175(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Identification of VPS35 mutations replicated in French families with Parkinson disease."Neurology 78:1449-1450(2012) [PubMed] [Europe PMC] [Abstract]