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Never In Mitosis Gene A Related Kinase 7 (NEK7)

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NIMA Related Kinase 7; Serine/threonine-protein kinase Nek7

Never In Mitosis Gene A Related Kinase 7 (NEK7)
CCC P415
HGNC 13386
MGI 1890645
PubMed 23313050
RGD 1311160
UniProt Q8TDX7
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.
The deduced 302-amino acid protein has a predicted molecular mass of 34.5 kD. It contains 12 conserved regions characteristic of protein kinase catalytic domains, including a DIKPAN motif that suggests serine/threonine kinase activity. Human NEK7 shares 97%, 77%, 77%, and 64% sequence identity with mouse Nek7, human NEK6 , mouse Nek6, and C. elegans F19H6.1. highest expression of NEK7 in lung, muscle, testis, brain, heart, liver, leukocyte, and spleen. Faint bands were detected in ovary, prostate, and kidney, and no transcript was amplified from small intestine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 7 (NEK7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 7 (NEK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 7 (NEK7) Polyclonal Antibody Customized Service Offer
Assay Kits SEP415Hu ELISA Kit for Never In Mitosis Gene A Related Kinase 7 (NEK7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 7 (NEK7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 7 (NEK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 7 (NEK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 7 (NEK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 7 (NEK7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 7 (NEK7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 7 (NEK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 7 (NEK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 7 (NEK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 7 (NEK7) ELISA Kit Customized Service Offer
  1. "Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3."Cytogenet. Cell Genet. 94:33-38(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases."J. Biol. Chem. 278:34897-34909(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression."FEBS Lett. 580:6489-6495(2006) [PubMed] [Europe PMC] [Abstract]
  5. "NEK7 is a centrosomal kinase critical for microtubule nucleation."Biochem. Biophys. Res. Commun. 360:56-62(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis."Mol. Cell. Biol. 29:3975-3990(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain."BMC Struct. Biol. 11:12-12(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Mitotic regulation by NIMA-related kinases."Cell Div. 2:25-25(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9."Mol. Cell 36:560-570(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]