Zinc Finger Protein 212 (ZNF212)

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.Becker et al. (1997) reported the cloning of a C2H2-type, or Kruppel-related, zinc finger protein from a human hippocampus cDNA library. The partial cDNA, designated ZNF212, encodes a predicted 356-amino acid protein, with 4 C-terminal C2H2 zinc finger motifs and an N-terminal Kruppel-associated box (KRAB).