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Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17)

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ZNF151; ZNF60; MIZ1; pHZ-67; Myc-interacting zinc finger protein 1

Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17)
CCC P515
HGNC 12936
MGI 107410
PubMed 17947461
RGD 1307143
UniProt Q13105
Wiki ZBTB17
MIZ1 associates with microtubules, can bind directly to the low density lipoprotein receptor (LDLR) promoter, and can activate LDLR transcription. MIZ1 also binds to the promoter and activates transcription of other T113242 (a synthetic drug)-induced genes such as alpha-2 integrin.MIZ1 appears to be regulated by association with microtubules and may activate gene transcription in response to changes in the cytoskeleton.The deduced human MIZ1 protein shares 92% sequence identity with the closely related mouse protein Z13. MIZ1 has a potent growth arrest function; HeLa cells expressing recombinant MIZ1 progress into S phase but not into mitosis. MIZ1 can bind to and transactivate the adenovirus major late and cyclin D1 (CCND1) promoters.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 17 (ZBTB17) ELISA Kit Customized Service Offer
  1. "An alternative pathway for gene regulation by Myc."EMBO J. 16:5672-5686(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes."Genomics 13:999-1007(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc."Curr. Top. Microbiol. Immunol. 224:137-146(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1."J. Biol. Chem. 277:46799-46808(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter."Oncogene 22:351-360(2003) [PubMed] [Europe PMC] [Abstract]
  10. "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells."J. Biol. Chem. 279:15505-15514(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1."J. Cell. Biochem. 92:65-76(2004) [PubMed] [Europe PMC] [Abstract]
  12. "BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells."Nat. Immunol. 6:1054-1060(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1."Proc. Natl. Acad. Sci. U.S.A. 106:1433-1438(2009) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress."Nucleic Acids Res. 42:11447-11461(2014) [PubMed] [Europe PMC] [Abstract]
  16. "A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain."J. Mol. Biol. 373:820-826(2007) [PubMed] [Europe PMC] [Abstract]