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Zeta Chain Associated Protein Kinase 70kDa (zAP70)

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STD; SRK; Syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70

Zeta Chain Associated Protein Kinase 70kDa (zAP70)
CCC P541
HGNC 12858
MGI 99613
PubMed 17028588
RGD 3983
UniProt P43403
Wiki Zap-70
ZAP70 encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.ZAP70 associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural killer cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP541Hu01 Recombinant Zeta Chain Associated Protein Kinase 70kDa (zAP70) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP541Hu01 Polyclonal Antibody to Zeta Chain Associated Protein Kinase 70kDa (zAP70) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Zeta Chain Associated Protein Kinase 70kDa (zAP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zeta Chain Associated Protein Kinase 70kDa (zAP70) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP541Mu01 Recombinant Zeta Chain Associated Protein Kinase 70kDa (zAP70) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP541Mu01 Polyclonal Antibody to Zeta Chain Associated Protein Kinase 70kDa (zAP70) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Zeta Chain Associated Protein Kinase 70kDa (zAP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zeta Chain Associated Protein Kinase 70kDa (zAP70) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zeta Chain Associated Protein Kinase 70kDa (zAP70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zeta Chain Associated Protein Kinase 70kDa (zAP70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zeta Chain Associated Protein Kinase 70kDa (zAP70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zeta Chain Associated Protein Kinase 70kDa (zAP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zeta Chain Associated Protein Kinase 70kDa (zAP70) ELISA Kit Customized Service Offer
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