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Wee1 Like Protein Kinase (WEE1)

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Wee1A kinase

Wee1 Like Protein Kinase (WEE1)
CCC P554
HGNC 12761
MGI 103075
PubMed 21859861
RGD 1307895
UniProt P30291
Wiki Wee1
WEE1 is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.The human WEE1 gene is expressed as a 3-kb mRNA that encodes a predicted 432-amino acid protein. Human WEE1 has 29% amino acid identity to S. pombe wee1 protein in the central serine/threonine kinase domain.The human WEE1 tyrosine kinase appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. The kinase domain of human WEE1 was sufficient to complement the fission yeast wee1 mutation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wee1 Like Protein Kinase (WEE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wee1 Like Protein Kinase (WEE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wee1 Like Protein Kinase (WEE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wee1 Like Protein Kinase (WEE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wee1 Like Protein Kinase (WEE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wee1 Like Protein Kinase (WEE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wee1 Like Protein Kinase (WEE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wee1 Like Protein Kinase (WEE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wee1 Like Protein Kinase (WEE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wee1 Like Protein Kinase (WEE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wee1 Like Protein Kinase (WEE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wee1 Like Protein Kinase (WEE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wee1 Like Protein Kinase (WEE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wee1 Like Protein Kinase (WEE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wee1 Like Protein Kinase (WEE1) ELISA Kit Customized Service Offer
  1. "Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle."EMBO J. 14:1878-1891(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Wee1(+)-like gene in human cells."Nature 353:80-83(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15."EMBO J. 12:75-85(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function."J. Biol. Chem. 279:31164-31170(2004) [PubMed] [Europe PMC] [Abstract]
  8. "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP."Proc. Natl. Acad. Sci. U.S.A. 101:4419-4424(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity."J. Cell Sci. 123:286-294(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit."Nat. Commun. 3:894-894(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation."Structure 13:541-550(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]