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Ubiquitin Specific Peptidase 22 (USP22)

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USP3L; Ubiquitin carboxyl-terminal hydrolase 22; Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22

Ubiquitin Specific Peptidase 22 (USP22)
CCC P564
HGNC 12621
MGI 2144157
PubMed 22542455
UniProt Q9UPT9
Wiki USP22
USP22 contains 525 amino acids. It has an N-terminal zinc finger domain and a C-terminal ubiquitin hydrolase domain of the C19 class of peptidases.The deduced 593-amino acid protein shares significant identity with an S. pombe ubiquitin C-terminal hydrolase. The subunits of human SAGA that interacted with USP22 included TRRAP, ADA2 (TADA2L), ADA3 (TADA3L), TAF9L (TAF9B), TAF10, ATXN7, and the acetyltransferase GCN5 (KAT2A). Within SAGA, USP22 provided a deubiquitinating function and specifically deubiquitinated the core histone H2B. USP22 was required for transcriptional activation of specific MYC target genes, and depletion of USP22 compromised MYC functions, including cell transformation. Depletion of USP22 caused specific G1 cell cycle arrest.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 22 (USP22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 22 (USP22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 22 (USP22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 22 (USP22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 22 (USP22) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 22 (USP22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 22 (USP22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 22 (USP22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 22 (USP22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 22 (USP22) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The expression patterns of deubiquitinating enzymes, USP22 and Usp22."Gene Expr. Patterns 6:277-284(2006) [PubMed] [Europe PMC] [Abstract]
  5. "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing."Mol. Cell 29:92-101(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression."Mol. Cell 29:102-111(2008) [PubMed] [Europe PMC] [Abstract]
  7. "USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A."Cell Cycle 7:1522-1524(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]